Understanding Platelet-rich Fibrin

Platelet concentrates have been in clinical use for years, but platelet-rich fibrin has captured recent research because of its effect on bone and soft tissue healing. Richard J. Miron brings together researchers and clinicians from several specialties to set out the biology of PRF — fibrin matrix, growth factor release, cellular activity — and then to address what determines its quality: relative centrifugal force, horizontal versus angled centrifugation and the chemistry of the tubes. The second half carries it into the clinic: gingival recession, intrabony and furcation defects, implantology, maxillofacial surgery, endodontics and facial aesthetics. Data and protocol always travel together.