Periodontitis and Systemic Diseases: Clinical Evidence and Biological Plausibility

The relationship between periodontitis and systemic disease is often cited with more enthusiasm than rigour. Hirschfeld and Chapple bring together specialists from each field to examine, one by one, the associations described with diabetes, atherosclerotic cardiovascular disease, chronic kidney disease, rheumatoid arthritis, respiratory conditions, pregnancy, cancer, neurodegenerative disease and autoimmunity. Each chapter appraises the available studies critically, sets out the biological mechanisms that might underpin them and points to the methodological limitations still outstanding. A reference work for the clinician who has to explain these links to patients and for the researcher working on them.